Nebulised corticosteroid and amphotericin B: an alternative treatment for ABPA?

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Nebulised corticosteroid and amphotericin B: an alternative treatment for ABPA?

Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease that results from a hypersensitivity response to Aspergillus fumigatus [1]. It occurs in asthmatic and cystic fibrosis (CF) patients, with a prevalence among CF patients recently estimated at 7.8% [1]. The natural course is characterised by acute exacerbations, which can be life-threatening [2], and progressive, irreversible,...

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Efficacy of nebulised liposomal amphotericin B in the attack and maintenance treatment of ABPA.

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UNLABELLED Aspergillus species are the major life threatening fungal pathogens in transplant patients. Germination of inhaled fungal spores initiates infection, causes severe pneumonia, and has a mortality of >50%. This is leading to the consideration of pre-exposure prophylaxis to prevent infection. We made a very low MWt amphotericin B-polymethacrylic acid nanoparticle. It was not toxic to lu...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2008

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.00146707